This Cheesy Mexican Chicken Casserole is a fun layered casserole recipe that your whole family will devour! And, it’s a great way to use up leftover chicken or rotisserie chicken.

Need a different idea that will spice up taco Tuesdays? I love this Doritos Chicken Casserole recipe because it’s comfort food at it’s absolute best. This easy recipe layers refried beans, chips, corn, chicken, cheese and a cream sauce for a super satisfying, cheesy meal!

A photo of a slice of mexican chicken casserole being pulled out of a dish

I tend to make this recipe on busy weeknights because my work is limited to assembling the delicious casserole. Then, while this cheesy chicken casserole bakes, I have at least 30 minutes to do whatever I want! 

A photo of a slice of mexican chicken casserole

If you have a picky family member, you can always make them a small casserole dish of their own Cheesy Dorito Chicken Casserole. Just omit the items they don’t like!

a photo of mexican chicken casserole on a plate

My son is a bit picky, but if I omit the refried beans, he is happy. It does not take much time to make a separate, smaller dish while you assemble the main casserole dish.

a photo of condensed soup and spices in a bowl

Mexican Chicken Casserole Substitutions:

I used cooked, shredded chicken breasts, but this recipe would work well with boneless, skinless chicken thigh meat as well. Cooked ground beef and shredded pulled pork are great substitutes as well.

Substitute cheddar soup or cream of mushroom soup for the Cream of Chicken Soup.

Use regular tortilla chips instead of the nacho cheese Doritos. Or, use soft tortillas!

Use a Mexican-cheese blend or shredded cheddar cheese instead of Colby jack.

an overhead photo of a mexican chicken casserole in a large dish

Serving Suggestions:

I recommend serving this cheesy casserole with Cilantro Lime Brown Rice, Cilantro Lime Cole Slaw, Mexican Restaurant Style Rice or The Best Esquites Recipe (Street Corn Salad). Make an authentic Mexican drink for everyone to enjoy using this authentic Horchata recipe!

If you’re craving dessert, check this list of authentic Mexican desserts to add to the mix!

an overhead photo of a mexican chicken casserole

Storing Leftovers: 

Store leftover Doritos casserole in an airtight container in the refrigerator for up to 3 days. I like to reheat in the oven, covered with aluminum foil.

A photo of shredded cheese being spread over the top of a casserole.
a photo of a slice of cheesy Mexican Chicken Casserole

Easy Mexican Chicken Casserole

Yield: Serves 9-12
Prep Time: 15 minutes
Cook Time: 35 minutes
Additional Time: 5 minutes
Total Time: 55 minutes

This easy Mexican Chicken Casserole is creamy and SO cheesy! The perfect weeknight dinner.


For the creamy sauce layer:

  • 1 10-ounce can Cream of Chicken Soup
  • 1 4.5 ounce can green chiles
  • 1 tablespoon taco seasoning
  • 1 teaspoon garlic powder
  • 1 teaspoon onion powder

For the other layers:

  • 1 10-ounce can Rotel
  • 1 15-ounce can black beans, drained and rinsed
  • 1 15-ounce can refried beans
  • 1 15-ounce can whole kernel corn
  • 3 cups shredded cooked chicken
  • 2 cups Colby Jack cheese
  • 4 cups tortilla chips or Doritos, crushed

Optional garnishes:

  • cilantro
  • more chips, crushed
  • green onions
  • sour cream (add after baking)
  • avocado
  • hot sauce
  • tomatoes


  1. Preheat the oven to 350 degrees Fahrenheit. 
  2. In a large bowl, make the creamy sauce. Combine soup, taco seasoning, garlic powder, onion powder. Mix vigorously with a whisk until combined.
  3. Prepare a 9x13'' baking dish with non-stick cooking spray.
  4. Crumble about ½ cup of the chips into the bottom of the casserole dish.
  5. Layer ½ of the shredded chicken over the crushed chips. 
  6. Spoon half of the creamy soup mixture over the chicken, then half of the refried beans, half of the Rotel tomatoes and half of the corn and black beans. 
  7. Then, sprinkle half of the Colby jack cheese.
  8. Repeat the layers in the order of chips, chicken, creamy soup mixture, refried beans, Rotel tomatoes, corn and black beans. 
  9. Top the final layer with the rest of the cheese. 
  10. Bake in the preheated oven for 35-40 minutes, until the casserole is bubbling around the sides and beginning to brown on top. 
  11. Top with fresh cilantro, extra crushed chips, avocados, sour cream, cilantro or fresh tomatoes. 
Nutrition Information
Yield 12 Serving Size 1
Amount Per Serving Calories 399Total Fat 20gSaturated Fat 7gTrans Fat 0gUnsaturated Fat 11gCholesterol 53mgSodium 733mgCarbohydrates 36gFiber 8gSugar 3gProtein 21g

The nutrition for this recipe is calculated by an app and may be incorrect.

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