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This Cheesy Mexican Chicken Casserole is a fun layered casserole recipe that your whole family will devour! And, it’s a great way to use up leftover chicken or rotisserie chicken.

Need a different idea that will spice up taco Tuesdays? I love this Doritos Chicken Casserole recipe because it’s comfort food at its absolute best. This easy recipe layers refried beans, chips, corn, chicken, cheese and a cream sauce for a super satisfying, cheesy meal!

“This was amazing! My husband had seconds and can’t stop praising it. Will make again!” – Kristie

A photo of a slice of mexican chicken casserole being pulled out of a dish

I tend to make this recipe on busy weeknights because my work is limited to assembling the delicious casserole. Then, while this cheesy chicken casserole bakes, I have at least 30 minutes to do whatever I want! 

A photo of a slice of mexican chicken casserole

If you have a picky family member, you can always make them a small casserole dish of their own Cheesy Dorito Chicken Casserole. Just omit the items they don’t like!

a photo of mexican chicken casserole on a plate

My son is a bit picky, but if I omit the refried beans, he is happy. It does not take much time to make a separate, smaller dish while you assemble the main casserole dish.

I think these cheesy casseroles like Walking Taco Casserole and King Ranch Casserole are pretty easy to customize to your tastes, which only adds to their appeal!

a photo of condensed soup and spices in a bowl

Mexican Chicken Casserole Substitutions

I used cooked, shredded chicken breasts, but this recipe would work well with boneless, skinless chicken thigh meat as well. Cooked ground beef and shredded pulled pork are great substitutes as well.

Substitute cheddar soup or cream of mushroom soup for the Cream of Chicken Soup.

Use regular tortilla chips instead of the nacho cheese Doritos. Or, use soft tortillas!

Use a Mexican-cheese blend or shredded cheddar cheese instead of Colby jack. Or, substitute the shredded cheese layers with this RoTel dip with no meat!

an overhead photo of a mexican chicken casserole in a large dish

Serving Suggestions for Mexican Chicken Casserole

I recommend serving this cheesy casserole with Cilantro Lime Brown Rice or Air Fryer Mexican Rice, Cilantro Lime Cole Slaw, Mexican Restaurant Style Rice, or this Esquites Recipe.

Make an authentic Mexican drink for everyone to enjoy using this authentic Horchata recipe or Paloma mocktail!

If you’re craving dessert, check this list of authentic Mexican desserts to add to the mix!

an overhead photo of a mexican chicken casserole

Storing Leftovers

Store leftover Doritos casserole in an airtight container in the refrigerator for up to 3 days. I like to reheat in the oven, covered with aluminum foil.

A photo of shredded cheese being spread over the top of a casserole.

I hope that you enjoy this Mexican casserole recipe! If you give it a try, let me know in the comments below.

a photo of a slice of cheesy Mexican Chicken Casserole

Easy Mexican Chicken Casserole

Yield: 9
Prep Time: 15 minutes
Cook Time: 35 minutes
Additional Time: 5 minutes
Total Time: 55 minutes
Author: Michelle Goth
This easy Mexican Chicken Casserole is creamy and SO cheesy! The perfect weeknight dinner.
4.94 from 59 ratings
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Ingredients
 

For the creamy sauce layer:

  • 10 ounces cream of chicken soup, 1 can
  • 4.5 ounces green chiles, canned
  • 1 tablespoon taco seasoning
  • 1 teaspoon garlic powder
  • 1 teaspoon onion powder

For the other layers:

  • 10 ounces Rotel
  • 15 ounces black beans, canned, drained and rinsed
  • 15 ounces refried beans, canned
  • 15 ounces whole kernel corn, canned
  • 3 cups shredded cooked chicken
  • 2 cups Colby Jack cheese
  • 4 cups tortilla chips or Doritos, whole or crushed

Optional garnishes:

  • cilantro
  • more chips, crushed
  • green onions
  • sour cream, add after baking
  • avocado
  • hot sauce
  • tomatoes

Instructions
 

  • Preheat the oven to 350 degrees Fahrenheit. 
  • In a large bowl, make the creamy sauce. Combine soup, taco seasoning, garlic powder, onion powder. Mix vigorously with a whisk until combined.
  • Prepare a 9×13'' baking dish with non-stick cooking spray.
  • Crumble about 1/2 cup of the chips into the bottom of the casserole dish.
  • Layer 1/2 of the shredded chicken over the crushed chips. 
  • Spoon half of the creamy soup mixture over the chicken, then half of the refried beans, half of the Rotel tomatoes and half of the corn and black beans. 
  • Then, sprinkle half of the Colby jack cheese.
  • Repeat the layers in the order of chips, chicken, creamy soup mixture, refried beans, Rotel tomatoes, corn and black beans. 
  • Top the final layer with the rest of the cheese. 
  • Bake in the preheated oven for 35-40 minutes, until the casserole is bubbling around the sides and beginning to brown on top. 
  • Top with fresh cilantro, extra crushed chips, avocados, sour cream, cilantro or fresh tomatoes. 
Serving: 1, Calories: 362kcal, Carbohydrates: 28g, Protein: 27g, Fat: 15g, Saturated Fat: 7g, Polyunsaturated Fat: 2g, Monounsaturated Fat: 5g, Cholesterol: 65mg, Sodium: 856mg, Potassium: 447mg, Fiber: 7g, Sugar: 3g, Vitamin A: 473IU, Vitamin C: 6mg, Calcium: 251mg, Iron: 3mg
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